Sung I. Koo, Ph.D.

Professor EmeritusPicture of Professor Emeritus Koo

Phone:  (860) 486-3495
Email:   sung.koo@uconn.edu

EDUCATION

    • B.S. in Animal Science: Kon-Kuk University, Seoul, Korea, February 1970. Korea University College of Arts and Sciences, Seoul, Korea.
    • M.S. in Animal Nutrition: University of New Hampshire, Durham, NH.
    • Ph.D. in Nutrition (Nutritional Biochemistry): Clemson University, Clemson, SC.
    • Postdoctoral training in nutritional biochemistry and gastrointestinal physiology: Cornell University School of Veterinary Medicine, Ithaca, NY, (Mentor: Robert Wasserman, Ph.D., Professor).

PROFESSIONAL APPOINTMENTS

    • Professor: 2002 – present, Department of Nutritional Sciences, University of Connecticut, Storrs, CT.
    • Professor and graduate faculty: 1990 – 2002, Department of Human Nutrition, Kansas State University, Manhattan, KS.
    • Adjunct Graduate Faculty: 1991 – 2002, Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS.
    • Professor: 1989 – 1990, Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK.
    • Associate Professor: 1984 – 1989, Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK.
    • Assistant Professor: 1979 – 1984, Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK.
    • Research Associate: 1976 – 1978, Department of Physiology, Cornell University School of Veterinary Medicine, Ithaca, NY.

ADMINISTRATIVE APPOINTMENTS

    • Department Head, Department of Nutritional Sciences, University of Connecticut, 2002-2018.
    • Assistant Department Head, Department of Human Nutrition, Kansas State University, 1999-2002.
    • Graduate Program Coordinator, Department of Human Nutrition, Kansas State University, 1998-2002.
    • Human Nutrition Panel Manager, USDA National Research Initiative Competitive Grants Programs 1999-2001.
    • Nutrition Coordinator with Dietetics, Kansas State University, 1997.
    • Human Nutrition Coordinator, Oral Roberts University School of Medicine, 1985-1990.

PROFESSIONAL SOCIETY MEMBERSHIPS

    • American Society for Nutrition (ASN)
    • Institute of Food Technologists (IFT)

EDITORIAL BOARDS

    • Journal of Nutritional Biochemistry, 2001 – present.
    • American Journal of Physiology: Gastrointestinal & Liver Physiology, 2003 – 2009.
    • Journal of Nutrition, 2002 – 2008.
    • Nutraceuticals and Food, 2002 – 03.
    • Journal of Food Science and Nutrition, 1998 – 02.

REVIEW PANELS & ADVISORY BOARDS

    • USDA NIFA Food Safety, Nutrition, and Health: Function and Efficacy of Nutrients Panel 2015 -2017
    • USDA NIFA Food Safety, Nutrition, and Health: Function and Efficacy of Nutrients Panel 2013
    • USDA NIFA Fellowships Program Panel Manager 2010
    • USDA AFRI Bioactive Food Components for Optimal Health Grants Review Panel 2009
    • USDA NRI Bioactive Food Components Grants Review Panel 2008
    • USDA Higher Education Multicultural Scholars Program Review Panel 2007
    • Florida State University Department of Nutrition, Food & Exercise Sciences External Advisory Board, 2006-2008.
    • NIH NationalCenter for Complementary and Alternative Medicine Panel, 2004.
    • University of Kentucky Superfund Program External Advisory Board, 2003-2006.
    • University of Kentucky Tobacco & Health Research Institute, 2002.
    • USDA NRI Competitive Grants Program Human Nutrition Panel Manager, 1999-2001.
    • USDA Initiative for Future Agriculture and Food System (IFAFS) Functional Foods Panel, 2001.
    • USDA Multidisciplinary Graduate Education and Traineeship Program, 2001.
    • NIH National Center for Complementary and Alternative Medicine Panel, 1999-2001.
    • US Department of Veterans Affairs Merit Review, 2001.
    • Philip Morris External Research Program, 2000-2003.
    • NIH NCCAM Special Emphasis Panel on Botanical Research Centers, 2000.
    • Auburn University Biogrant Program, 2000.
    • USDA NRI Competitive Grants Program Human Nutrition Panel, 1997-1999.
    • The City University of New York (CUNY) Grant Program, 1997.
    • American Heart Association Kansas Affiliate Peer Review Committee, 1994-1997.
    • American Heart Association Kansas Affiliate Research Committee, 1994-1997.
    • USDA NRI Competitive Grants Program Human Nutrition Ad Hoc Reviewer, 1994-1996.
    • USDA ARS Research Project Merit Review, 1994.
    • NIH National Center for Nursing, Nursing and Biology Interface Program, Study Section, 1992.
    • Natural Sciences and Engineering Research Council of Canada Research Grants, 1992.

AWARDS AND HONORS

    • Faculty Research Excellence Award: College of Human Ecology, KSU, 1994.
    • Faculty Research Excellence Award: College of Human Ecology, KSU, 2002.
    • New Investigator Award: National Institute of Health (NIH) 1983-1986.

COURSES TAUGHT

    • Advanced Macronutrient Metabolism (graduate), 1998 – 2002
    • Nutrient Metabolism (undergraduate): 1995 – 2002
    • Advanced Nutrition: Proteins and Amino Acids (graduate): 1990 – 1998
    • Advanced Nutrition: Carbohydrates and Lipids (graduate): 1991 – 1998
    • Nutritional Biochemistry (Bionutrition: graduate): 1991 – 1995
    • Advanced Nutrition: Fat-Soluble Vitamins (graduate): 1991
    • Biochemical Techniques: 1979 – 90
    • Medical Biochemistry: 1979 – 90
    • Medical Human Nutrition: 1981 – 89
    • Medical Nutrition Elective: 1981 – 83
    • Undergraduate Biochemistry (Course Director): 1981 – 85
    • Amino Acid Biochemistry: 1981 – 83

RESEARCH

    • Mechanisms of intestinal absorption of lipids and lipid-soluble vitamins
    • Dietary phytochemicals and lipid metabolism

GRANTS

    • NIH National Center for Complementary and Alternative Medicine, Hypocholesterolemic action of green tea extracts Principal Investigator; April 1, 2004-March 31, 2006
    • Lonza Inc. A clinical study on the effect of L-carnitine on the loss of fat during weight reduction; Principal Investigator with Dr. Maria Luz Fernandez, CoPI ; Sept 1, 2002 – Aug 31, 2004.
    • Lonza Inc. Dietary L-carnitine supplement: Its effect on fat-soluble vitamin status in an aging female rat model.; September 1, 2002 – August 31, 2004.
    • USDA – NRI Competitive Research Grants Program, Role of vitamin A in lung epithelial cell repair. Co-Investigator with Richard Baybutt, PI, KSU; Sept 1, 1999 – Aug 31, 2002.
    • American Heart Association Heartland Affiliate; Synthesis and biological evaluation of cholesteryl ester transfer protein inhibitors: chloropuupehenone and its analogs; Co-Principal Investigator with Duy Hua, Department of Chemistry, KSU); July 1, 2000 – June 30, 2002.
    • USDA- NRI Competitive Research Grants Program, Zinc deficiency: Its effect on vitamin A transport; Principal Investigator; September 1, 1996 – August 31, 2001.
    • Hill’s Science and Technology Center; The Role of carnitine in fatty acid metabolism; Principal Investigator, ; July 1, 1997 – June 30, 2001.
    • Lonza Inc.; Effects of modified tall oil on body composition in rats when fed in conjunction with other nutritional supplements; Principal Investigator; ; Oct 22, 1999 – April 21, 2000.
    • AMPC (Proliant), Inc.; The effect of a bovine plasma IgG fraction on lymphatic absorption of cholesterol in a rat model; Principal Investigator; September 1, 1998 – December 31, 2002.
    • The American Heart Association, Kansas Affiliate; Estrogen replacement: Its effect on intestinal fat absorption, Principal Investigator; August 1, 1995 – July 31, 1997.
    • The American Heart Association, Kansas Affiliate; Effect of estrogen replacement and dietary copper on cholesterol metabolism in ovariectomized rats; Principal Investigator August 1, 1991 – December 31, 1994.
    • USDA- NRI Competitive Research Grants Program; Zinc deficiency: Its effect on vitamin A transport; Principal Investigator September 1, 1990 – August 31, 1993.
    • The National Live Stock and Meat Board; In-vivo clearance of chylomicrons enriched with stearic acid; Principal Investigator; June 1, 1991 – December 31, 1992.
    • NIH, National Heart, Lung and Blood Institute Grant (RO1); Cholesterol transport: Effect of zinc and copper nutrition; Principal Investigator July 1, 1986 – June 30, 1989.
    • National Institutes of Health (NIH) New Investigator Award (R29) Zinc nutrition and intestinal absorption of cholesterol; Principal Investigator; January 1, 1983 – June 30, 1986.

PUBLICATIONS

    • Yang Y, Bae M, Park YK, Lee Y, Pham TX, Rudraiah S, Manautou J, Koo SI, Lee JY. Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells. J Nutr Biochem. 2017 Feb; 40:172-177.
    • Lee SG, Wang T, Vance TM, Hubert P, Kim DO, Koo SI, Chun OK.Validation of Analytical Methods for Plasma Total Antioxidant Capacity by Comparing with Urinary 8-Isoprostane Level. J Microbiol Biotechnol. 2017 Feb 28;27(2):388-394.
    • Kim B, Lee SG, Park YK, Ku CS, Pham TX, Wegner CJ, Yang Y, Koo SI, Chun OK, Lee JY Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice. Nutr Res Pract. 2016 Oct;10(5):494-500.
    • Kim B, Farruggia C, Ku CS, Pham TX, Yang Y, Bae M, Wegner CJ, Farrell NJ, Harness E, Park YK, Koo SI, Lee JY. Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. J Nutr Biochem. 2016 Mar 2;43:27-35. doi: 10.1016/j.
    • Zheng X, Mun S, Lee SG, Vance TM, Hubert P, Koo SI, Lee SK, Chun OK. Anthocyanin-rich blackcurrant extract attenuates ovariectomy-induced bone loss in mice. J Med Food. 2016 Apr;19(4):390-7. doi: 10.1089/jmf.2015.0148.
    • Lee BH, Nam TG, Park NY, Chun OK, Koo SI, Kim DO. Estimated daily intake of phenolics and antioxidants from green tea consumption in the Korean diet. Int J Food Sci Nutr. 2016, 67; 344–352.
    • Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Siah Ku C, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease. Hepatology. 2016 Apr;63(4):1190-204.
    • Yang Y, Bae M, Kim B, Park YK, Koo SI, Lee JY. Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. J Nutr Biochem. 2016 Mar; 29:21-6. doi: 10.1016/j.
    • Vance TM, Azabdaftari G, Pop EA, Lee SG, Su LJ, Fontham ET, Bensen JT, Steck SE, Arab L, Mohler JL, Chen MH, Koo SI, Chun OK. Intake of dietary antioxidants is inversely associated with biomarkers of oxidative stress among men with prostate cancer. Br J Nutr. 2015 Nov 2:1-7. [Epub ahead of print]
    • Lee SG, Vance TM, Nam TG, Kim DO, Koo SI, Chun OK. Contribution of Anthocyanin Composition to Total Antioxidant Capacity of Berries. Plant Foods Hum Nutr. 2015 Oct 29. [Epub ahead of print]
    • Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Siah Ku C, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease. Hepatology. 2015 Sep 24. doi: 10.1002/hep.28245.
    • Vance TM, Azabdaftari G, Pop EA, Lee SG, Su LJ, Fontham ET, Bensen JT, Steck SE, Arab L, Mohler JL, Chen MH, Koo SI, Chun OK. Thioredoxin 1 in prostate tissue is associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants. Prostate Cancer. 2015;2015:728046. doi: 10.1155/2015/728046.
    • Yang Y, Kim B, Park YK, Koo SI, Lee JY.Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochim Biophys Acta. 2014 Oct 23;1850(1):178-185. doi: 10.1016/j.bbagen.2014.10.014. [Epub ahead of print]
    • Lee SG, Kim B, Soung DY, Vance T, Lee JS, Lee JY, Koo SI, Kim DO, Drissi H, Chun OK. Relationship between oxidative stress and bone mass in obesity and effects of berry supplementation on bone remodeling in obese male mice: An Exploratory Study. J Med Food. 2014 Sep 8. [Epub ahead of print]
    • Yoo HG, Lee BH, Kim W, Lee JS, Kim GH, Chun OK, Koo SI, Kim DO. Lithospermum erythrorhizon extract protects keratinocytes and fibroblasts against oxidative stress. J Med Food. 2014 Aug 19. [Epub ahead of print]
    • Lee SG, Yang M, Wang Y, Vance T, Lloyd B, Chung SJ, Koo SI, Chun OK. Impact of Orange Juice Consumption on Bone Health of the U.S. Population in the National Health and Nutrition Examination Survey 2003-2006. J Med Food. 2014 Jul 23. [Epub ahead of print]
    • Wang Y, McCullough M, Chung S, Song WO, Fernandez M-L, Koo SI, Chun OK. Dietary carotenoids are associated with cardiovascular disease risk biomarkers mediated by serum carotenoid concentrations. J Nutr. 2014 Jul;144(7):1067-74. doi: 10.3945/jn.113.184317. Epub 2014 Apr 17.
    • Lee SG, Kim B, Yang Y, Pham TX, Park YK, Manatou J, Koo SI, Chun OK, JY Lee. Berry anthocyanins suppress the expression and secretin of pro-inflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kB independent of NRF2-mediated mechanism. J Nutr Biochem. 2013 Dec 31. pii: S0955-2863(13)00261-1. doi: 10.1016/j.jnutbio.2013.12.001. [Epub ahead of print]
    • Wang Y, Yang M, Lee SG, Davis CG, Koo SI, Fernandez ML, Volek JS, Chun OK. Diets high in total antioxidant capacity improve risk biomarkers of cardiovascular disease: a 9-month observational study among overweight/obese postmenopausal women. Eur J Nutr. 2013 Dec 17. [Epub ahead of print]
    • Masterjohn C, Park Y, Lee J, Noh SK, Koo SI, Bruno RS. Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2. Nutrients 2013; 5(8), 3311-3328; doi:10.3390/nu5083311.
    • Vance TM, Su J, Fontham ETH, Koo SI, Chun OK. Dietary Antioxidants and Prostate Cancer: A review. Nutr Cancer. 2013;65(6):793-801. doi: 10.1080/01635581.2013.806672.
    • Liu CS, Nam TG, Han MW, Ahn SM, Choi HS, Kim TY, Chun OK, Koo SI, Kim DO. Protective Effect of Detoxified Rhus verniciflua Stokes on Human Keratinocytes and Dermal Fibroblasts against Oxidative Stress and Identification of the Bioactive Phenolics. Biosci Biotechnol Biochem. 2013;77(8),1682-88 Aug 7. [Epub ahead of print]
    • Yang M, Wang Y, Davis CG, Lee SG, Fernandez ML, Koo SI, Cho E, Chun OK. Validation of an FFQ to assess antioxidant intake in overweight postmenopausal women. Public Health Nutr 2013 2013 Jun 26:1-9. [Epub ahead of print]
    • Im SE, Nam TG, Lee H, Han MW, Heo HJ, Koo SI, Lee CY, Kim DO. Anthocyanins in the ripe fruits of Rubus coreanus Miquel and their protective effect on neuronal PC-12 cells. Food Chem. 2013 Aug 15;139(1-4):604-10. doi: 10.1016/j.foodchem.2012.12.057. Epub 2013 Jan 16.
    • Yang M, Chung SJ, Floegel A, Song WO, Koo SI, Chun OK. Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations  Eur J Nutr. 2013 Jan 4. [Epub ahead of print]
    • Yang M, Wang Y, Davis CG, Lee SG, Fernandez ML, Koo SI, Cho E, Song WO, Chun OK.Validation of an FFQ to assess short-term antioxidant intake against 30 d food records and plasma biomarkers. Public Health Nutr. 2012 Nov 20:1-10. [Epub ahead of print]
    • Wang Y, Yang M, Lee SG, Davis CG, Koo SI, Chun OK. Dietary total antioxidant capacity is associated with diet and plasma antioxidant status in healthy young adults. J Acad Nutr Diet. 2012 Oct;112(10):1626-35. doi: 10.1016/j.jand.2012.06.007.
    • Wang Y, Yang M, Lee SG, Davis CG, Kenny A, Koo SI, Chun OK. Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women. J Nutr Biochem. 2012 May 21. [Epub ahead of print]
    • Park HJ, Lee JY, Chung MY, Park YK, Bower AM, Koo SI, Giardina C, Bruno RS. Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis. J Nutr. 2012 Jan;142(1):57-63. Epub 2011 Dec 7.
    • Kim J, Koo SI, Noh SK. Green tea extract markedly lowers the lymphatic absorption and increases the biliary secretion of (14)C-benzo[a]pyrene in rats. J Nutr Biochem. 2012 Aug;23(8):1007-11. Epub 2011 Oct 13.
    • Lee J-Y, Park Y, Koo SI. ATP-binding cassette transporter A-I and HDL metabolism: Effects of fatty acids. J Nutr Biochem. 2011 Jun 16. [Epub ahead of print] PMID: 21684139
    • Floegel A, Kim DO, Chung SJ, Koo SI, Chun OK. Comparison of ABTS and DPPH assays for determination of total antioxidant capacity of 50 antioxidant-rich U.S. foods. J Food Comp Analysis. 2011, 24:1043-48.
    • Masterjohn C, Mah E, Guo Y, Koo SI, Bruno RS. γ-Tocopherol abolishes postprandial increases in plasma methyglyoxal following an oral dose of glucose in healthy, college-aged men. J Nutr Biochem. 2011 May 2. [Epub ahead of print].
    • Chung MY, Park HJ, Manautou JE, Koo SI, Bruno RS. Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by pro-inflammatory enzymes. J Nutr Biochem. 2011 May 2. [Epub ahead of print].
    • Floegel A, Chung SJ, von Ruesten A, Yang M, Chung CE, Song WO, Koo SI, Pischon T, Chun OK. Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in U.S. adults: a cross-sectional study. Public Health Nutr. 2011 Mar 18:1-10. [Epub ahead of print].
    • Yang M, Chung SJ, Eun Chung C, Kim DO, Song WO, Koo SI, Chun OK.  Estimation of total antioxidant capacity from diet and supplements in US adults. Br J Nutr. 2011 Feb 15:1-11. [Epub ahead of print]
    • Yang M, Koo SI, Song WO, Chun OK. Food matrix affecting anthocyanin bioavailability: Review. Curr Med Chem 2010 Nov 29. [Epub ahead of print]
    • Park HJ, DiNatale DA, Chung MY, Park Y-K, Lee J-Y, Koo SI, O’Connor M, Manautou JE, Bruno RS. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem [2010 Jul 22. [Epub ahead of print]
    • Floegel A, Kim DO, Chung SJ, Song WO, Fernandez ML, Bruno RS, Koo SI, Chun OK. Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet. Int J Food Sci Nutr 61:600-23, 2010.
    • Chun OK, Floegel A, Chung SJ, Chung CE, Song WO, Koo SI. Estimation of antioxidant intakes from diet and supplements in U.S. adults. J Nutr 140:317-24, 2010. [Erratum in: J Nutr. 2010 140:1062].
    • Iwaniec UT, Turner RT, Koo SI, Kaur R, Ho E, Wong CP, Bruno RS. Consumption of green tea extract results in osteopenia in growing male ob/ob mice. J Nutr 139:1914-1919, 2009.
    • Shrestha, S., Ehlers, S.J., Lee, J-Y., Fernandez, M-L, and Koo, S.I. Dietary green tea extract lowers plasma and hepatic triglyceride and decreases the expression of SREBP-1c mRNA and its responsive genes in fructose-fed ovariectomized rats. J. Nutr. 139:640-645, 2009.
    • Pasiakos, S.M., Mettel, J.B., West, K., Lofgren, I.E., Fernandez, M.L., Koo, S.I. and Rodriguez, N.R. Maintenance of resting energy expenditure after weight loss in premenopausal women: potential benefits of high protein and reduced-calorie diet. Metabolism 57: 458-464, 2008.
    • Hooshmand S, Balakrishnan A, Clark RM, Owen KQ, Koo SI, and Arjmandi BH. Dietary L-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Phytomedicine 15:595-601, 2008.
    • Bruno, R.S., Dugan, C.E., Smyth, J.A., DiNatale, D.A., and Koo, S.I. Green tea extract protects against hepatic steatosis and injury in leptin deficient, spontaneously obese mice. J. Nutr. 138:323-331, 2008.
    • Woodworth, J.C., Tokach, M.D., Nelssen, J.L., Goodband, R.D., Dritz, S.S., Koo, S.I., Minton. J.E., and Owen K.Q. Influence of dietary L-carnitine and chromium picolinate on blood hormones and metabolites of gestating sows fed one meal per day. J Anim Sci. 85:2524-37, 2007.
    • Clark, R.M., Balakrishnan, A., Waters, D., Aggarwal D., Owen, K.Q., Koo, S.I. L-Carnitine increases liver α-tocopherol and lowers liver and plasma triglycerides in aging ovariectomized rats. J. Nutr. Biochem. 18: 623-628, 2007.
    • Hennig, B., Ettinger, A., Jandacek, R.J., Koo, S.I., McClain, C., Seifried, H., Silverstone, A., Watkins, B., and Suk, W.A. Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ. Health. Perspect. 493-495, 2007.
    • Koo, S.I. and Noh, S.K. Green tea as inhibitor of the intestinal absorption of lipids: Potential mechanism for its lipid-lowering effect. J. Nutr. Biochem. 18:179-183, 2007.
    • Wang, S., Noh, S.K. and Koo, S.I. Epigallocatechin gallate and caffeine differentially inhibit the intestinal absorption of cholesterol and fat in ovariectomized rats. J. Nutr. 136: 2791-2796, 2006.
    • Wang, S., Noh, S.K. and Koo, S.I. Green tea catechins inhibit pancreatic phospholipase A2 and intestinal absorption of lipids in ovariectomized rats. J. Nutr. Biochem. 17: 492-498, 2006.
    • Lofgren, I., Zern, T., Herron, K., West, K.L., Sharman, J.,Volek, J.F., Shachter, N.S., Koo, S.I. and Fernandez, M-L. Weight loss reduces the atherogenicity of LDL in premenopausal women. Metabolism, 54:1133-1141, 2005.
    • Zou, W., Noh, S.K., Owen, K.Q. and Koo, S.I. Dietary L-carnitine enhances the lymphatic absorption of fat and a-tocopherol in ovariectomized rats. J. Nutr. 135: 753-756, 2005.
    • Patalay, M., Lofgren, I.E., Freake, H., Koo, S.I. and Fernandez, M-L. The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase. J. Nutr. 135: 735-739, 2005.
    • Lofgren, I., Herron, K.,West, K., Zern, T., Patalay, M., Koo, S.I. and Fernandez, M-L. Relationships of carbohydrate intake and coronary disease biomarkers in a population of overweight premenopausal women. J. Nutr. Biochem. 16: 245-250, 2005.
    • Noh, S.K. and Koo, S.I. Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats. J. Nutr. 134:2611-2616, 2004.
    • Duy, H.H., Huang, X., Chen, Y., Battina, S.K., Tamura, M., Noh, S.K., Koo, S.I., Namatame, I. and Tomoda, H. Total Syntheses of (+)-Chloropuupehenone, (+)-Chloropuupehenol, And Their Analogs, And Evaluation of Bioactivities. J. Organic Chem. 69: 6065-6078, 2004.
    • Lofgren, I., Herron, K., Zern, T., West, K., Patalay, M., Schachter, N.S., Koo, S.I. and Fernandez, M.L. Waist circumference is a better predictor than body mass index for coronary heart disease risk in overweight premenopausal women. J. Nutr. 134: 1071-1076, 2004.
    • Woodworth, J.C., Minton, J.E., Tokach, M.D., Nelssen, J.L., Goodband, R.D., Dritz, S.S., Koo, S.I. and Owen K.Q. Dietary L-carnitine increases plasma leptin concentrations of gestating sows fed one meal per day. Domestic Anim. Endocrinol. 26: 1-9, 2004.
    • Noh, S.K. and Koo, S.I. Egg sphingomyelin lowers the lymphatic absorption of cholesterol and a-tocopherol in rats. J. Nutr. 133: 3571-3576, 2003.
    • Noh, S.K. and Koo, S.I. Low zinc intake decreases the lymphatic output of retinol in rats infused intraduodenally with beta-carotene. J. Nutr. Bioch. 14: 147-153, 2003.
    • Noh, S.K., Koo, S.I. and Y. Jiang. (+)-Catechin is a potent inhibitor of intestinal absorption of cholesterol in rats. Nutraceuticals & Food, 8: 1-6, 2003.
    • O’Quinn, P.R., Koo, S.I., Noh, S.K., Nelssen, J.L., Goodband, R.D. and Tokach, M.D. Effects of modified tall oil on body composition and serum and tissue levels of cholesterol, phospholipids, and alpha-tocopherol in adult ovariectomized rats. Nutr. Res. 23: 549-566, 2003.
    • Löest, L., Noh, S.K., and Koo, S.I. Green tea extract lowers the lymphatic absorption of cholesterol and alpha-tocopherol in ovariectomized rats. J. Nutr. 132:1282-1288, 2002.
    • Waylan, A.T., O’Quinn, P., Unruh, J.A., Nelssen, J.L., Goodband, R.D., Woodworth, J.C., Tokach, M.D., and Koo, S.I. Effects of modified tall oil and vitamin E on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. J. Anim. Sci. 80:1575-1585, 2002.
    • Koo, S.I. and Noh, S.K. Phosphatidylcholine inhibits and lysophosphatidylcholine enhances the lymphatic absorption of alpha-tocopherol in adult rats. J. Nutr. 131:717-722, 2001.
    • Jiang, Y., Noh, S.K., and Koo, S.I. Egg phosphatidylcholine decreases the lymphatic absorption of cholesterol in rats. J. Nutr. 131:2358-2363, 2001.
    • Noh, S.K. and Koo, S.I. Intraduodenal infusion of lysophosphatidylcholine restores the lymphatic absorption of vitamins A and E in rats fed a low zinc diet. Soc. Exp. Biol. Med. 226:342-348, 2001.
    • Noh, S.K. and Koo, S.I. Enteral infusion of phosphatidylcholine increases the lymphatic absorption of fat, but lowers the absorption of alpha-tocopherol in rats fed a low zinc diet. J. Nutr. Biochem. 12: 330-337, 2001.
    • Noh, S.K. and Koo, S.I. Feeding of a low zinc diet lowers the tissue concentrations of alpha-tocopherol in adult rats. Biol. Trace Elem. Res. 81:153-168, 2001.
    • Owen, K.Q., Ji, H., Maxwell, C.V., Nelssen, J.L., Goodband, R.D., Tokach, M.D., Tremblay, G.C., and Koo, S.I. Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. J. Anim. Sci.79:3104-3112, 2001.
    • Koo, S.I., Noh, S.K, Löest, H.B., and Wang, S. Green tea and its catechins as a dietary or pharmacologic means of lowering cholesterol absorption. Proc. Intl. Sym. Fd. Nutr. & Hlth for 21st Century. Korean Soc. Food Sci. Nutr. 74-89, 2001.
    • Noh, S.K., Koo, S.I., and Jeon, I.J. Estradiol replacement in ovariectomized rats increases the hepatic concentration and biliary secretion of a-tocopherol and polyunsaturated fatty acids. J. Nutr. Biochem. 10:110-117, 1999.
    • Kim, E.S., Noh, S.K., and Koo, S.I. Marginal zinc deficiency lowers the lymphatic absorption of a-tocopherol in rats. J. Nutr. 128:265-70, 1998.
    • Chung, H.J. and Koo, S.I. Estradiol replacement elevates the serum and tissue levels of a-tocopherol in ovariectomized rats. J. Nutr. Biochem. 9:67-74, 1998.
    • Yang, L. and Koo, S.I. Estradiol replacement and dietary copper in ovariectomized rats additively increase the serum levels of HDL-cholesterol and body status of copper. J. Trace Elements Exp. Med. 11:45-58, 1998.
    • Noh, S.K. and Koo, S.I. The lymphatic absorption of lipids is normalized by enteral phosphatidylcholine infusion in ovariectomized rats with estrogen replacement. J. Nutr. Biochem. 8:152-161, 1997.Yang, L. and Koo, S.I. Estradiol replacement lowers the lymphatic absorption of fatty acids and output of phospholipid. J. Nutr. Biochem. 7:214-221, 1996.
    • Ahn, J. and Koo, S.I. Effects of zinc and essential fatty acid deficiencies on the lymphatic absorption of vitamin A and secretion of phospholipids. J. Nutr. Biochem. 6:595-603, 1995.
    • Ahn, J. and Koo, S.I. Intraduodenal infusion of phosphatidylcholine restores the lymphatic absorption of vitamin A and oleic acid. J. Nutr. Biochem. 6:604-612, 1995.
    • Ahn, J. and Koo, S.I. Effect of zinc deficiency on the intestinal absorption, plasma clearance, and urinary excretion of 3H-vitamin A in rats. J. Trace Elements Exp. Med. 7:153-166, 1995.
    • Wang, S. and Koo, S.I. Plasma clearance and hepatic utilization of stearic, myristic, and linoleic acids introduced via chylomicrons in rats. Lipids 28:697-703, 1993.
    • Wang, S. and Koo, S.I. Evidence for distinct metabolic utilization of stearic acid in comparison with palmitic and oleic acids. J. Nutr. Biochem. 4:594-601, 1993.
    • Koo, S.I., Lee, C.C. and Sabin, L. The effect of copper deficiency on the hepatic synthesis and release of cholesterol. J. Nutr. Biochem. 4:162-167, 1993.
    • Koo, S.I., Lee, C.C., Scott, R.L. and Stone, W.L. Plasma clearance of human 125I-low density lipoproteins (LDL) in copper-deficient rats. J. Nutr. Biochem. 3:45-51, 1992.
    • Brenner, G.M. and Koo, S.I. Effect of different dosages of estradiol on copper and zinc status, and high density lipoproteins in ovariectomized rats. J. Trace Elements Exp. Med. 3:55-65, 1990.
    • Koo, S.I. and Lee, C.C. Effect of marginal zinc deficiency on endothelial lipoprotein lipase activities in postheparin plasma, skeletal muscle and adipose tissues. Lipids 24:132-136, 1989.
    • Koo, S.I. and Lee, C.C. Distribution of cholesterol and apolipoproteins in plasma high-density lipoprotein subclasses from marginally zinc-deficient rats. Am. J. Clin. Nutr. 50:73-79, 1989.
    • May, H.E. and Koo, S.I. The reversed-phase HPLC behavior of retinyl esters. J. Liquid Chromatography 12:1261-1280, 1989.
    • Lee, C.C. and Koo, S.I. Effect of copper deficiency on the composition of three high-density lipoprotein subclasses as separated by heparin-affinity chromatography. Biochim. Biophys. Acta 963:278-287, 1988.
    • Brenner, G.M. and Koo, S.I. Estradiol-induced increase in serum high-density lipoprotein cholesterol and its relationship with zinc and copper status in ovariectomized rats. Horm. Metabol. Res. 20:597-599, 1988.
    • Koo, S.I., Lee, C.C. and Norvell, J.E. Effect of copper deficiency on the lymphatic absorption of cholesterol, plasma chylomicron clearance, and postheparin lipase activities. Proc. Soc. Exp. Biol. Med. 118:410-419, 1988.
    • Lee, C.C. and Koo, S.I. Separation of three compositionally-distinct subclasses of rat high density lipoproteins by heparin-affinity chromatography. Atherosclerosis 70:205-215, 1988.
    • Carter, J.W. and Koo, S.I. Evaluation of the polychlorobiphenyl Aroclor 1254 in an animal model of atherosclerosis. Arch. Environ. Contamin. Toxicol. 17:307-312, 1988.
    • Koo, S.I. and Lee, C.C. Compositional changes in plasma high density lipoprotein particles from marginally zinc-deficient male rats. Am. J. Clin. Nutr. 47:120-127, 1988.
    • Koo, S.I., Lee, C.C. and Norvell, J.E. Effect of marginal zinc deficiency on the apolipoprotein-B content and size of mesenteric lymph chylomicrons in adult rats. Lipids 22:1035-1040, 1987.
    • Koo, S.I., Norvell, J.E., Algilani, K. and Chow, J. Effect of marginal zinc deficiency on the lymphatic absorption of 14C-cholesterol. J. Nutr. 116:2363-2371, 1986.
    • Koo, S.I., Dodds, S.J. and Mercer, L.P. Optimization of the dietary level of histidine in relation to the serum concentration of zinc and copper in weanling rats. Nutr. Res. 6:967-979, 1986.
    • Koo, S.I., Algilani, K., Norvell, J.E. and Henderson, D.A. Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginrally zinc-deficient rats. Am. J. Clin. Nutr. 43:429-437, 1986.
    • Koo, S.I., Henderson, D.A., Algilani, K. and Norvell, J.E. Effect of marginal zinc deficiency on the morphological characteristics of intestinal nascent chylomicrons and distribution of soluble apoproteins of lymph chylomicrons. Am. J. Clin. Nutr. 42:671-680, 1985.
    • Koo, S.I. and Ramlet, J.S. Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high-density lipoprotein cholesterol. Atherosclerosis 50:123-132, 1984.
    • Carter, J.W. and Koo, S.I. Effects of dietary Aroclor (PCBs) on serum levels of lipoprotein cholesterol and tissue distribution of zinc, copper and calcium in Fischer rats. Nutr. Rep. Int. 29:223-232, 1984.
    • Koo, S.I. and Winslow, S.L. A selective elevation in low-density lipoprotein cholesterol by 5 ppm of dietary cadmium. Nutr. Rep. Int. 27:131-136, 1983.
    • Koo, S.I. and Ramlet, J.S. Dietary cholesterol decreases the serum level of zinc: Further evidence for the positive relationship between serum zinc and high-density lipoproteins. Am. J. Clin. Nutr. 37:918-923, 1983.
    • Koo, S.I. and Williams, D.A. Relationship between the nutritional status of zinc and cholesterol concentration of serum lipoproteins in adult male rats. Am. J. Clin. Nutr. 34:2376-2381, 1981.
    • Koo, S.I. and Stanton, P. Effects of cellulose, pectin and guar gum on the distribution of serum cholesterol among lipoprotein fractions. Nutr. Rep. Int. 24:395-401, 1981.
    • Koo, S.I., Fullmer, C.S. and Wasserman, R.H. Effect of cholecalciferol and 1,25-dihydoxycholecalciferol on the intestinal absorption of zinc. J. Nutr. 110:1813-1818. 1980.
    • Koo, S.I., Currin, T.A., Johnson, M.G., King, E.W. and Turk, D.E. The nutritional value and microbial content of Musca Autumnalis. Poul. Sci. 59:2514-2518, 1980.
    • Koo, S.I., Fullmer, C.S. and Wasserman, R.H. Intestinal absorption and retention of 109Cd: Effect of cholecalciferol, calcium status and other variables. J. Nutr. 108:1812-1822, 1980.
    • Koo, S.I. and Turk, D.E. Effect of zinc deficiency on the intestinal transport of triglyceride in the rat. J. Nutr. 107:909-919, 1977.
    • Koo, S.I. and Turk, D.E. Effect of zinc deficiency on the ultrastructure of the pancreatic acinar cell and intestinal epithelium in the rat. J. Nutr. 107:896-908, 1977.

ABSTRACTS

    • Zheng X, Mun S, Lee SG, Vance T, Hubert P, Koo SI, Chun O. Black currant consumption attenuates ovariectomy-induced bone loss. FASEB#, 2014.
    • Vance T, Azabdaftari G, Pop E, Lee SG, Su J, Fontham ETH, Bensen JT, Mohler JL, Chen M-H, Koo SI, Chun OK. Level of cytoplasmic thioredoxin reductase 1 in prostate tissue associated with prostate cancer prevention score, total antioxidant capacity and erythrocyte glutathione peroxidase activity. FASEB#, 2014.
    • Kim B, Park YK, Koo SI, Lee JY. Role of polyphenol-rich blackcurrant and black chokeberry extracts in the stimulation of transintestinal cholesterol excretion in vitro. FASEB#, 2014.
    • Lee SG, Kim B, Yang Y, Park Y, Koo SI, Chun OK, Lee J. Berry anthocyanin fractions repress pro-inflammatory gene expression and secretion by inhibiting nuclear translocation of NF-kB in RAW 264.7 macrophages. FASEB#, 2013.
    • Kim B, Lee SG, Ku CS, Park Y, Yang Y, Pham TX, Wegner C, Koo SI, Chun OK, Lee J. Comparison of hypolipidemic effects of three berries in diet-induced obese C57BL/6J mice. FASEB#, 2013.
    • Lee SG, Vance T, Soung DY, Kim B, Lee J, Koo SI, Drissi HM, Chun OK. Blueberry and blackcurrant consumption increases bone mineral density and content in high fat diet-induced obese male mice. FASEB#, 2013.
    • Wegner C, Park Y, Koo SI, Lee J. Differential regulation of genes for intestinal cholesterol flux by epicatechin gallate and resveratrol in Caco-2 cells: potential role of histone deacetylases and sirtuins in intestinal cholesterol metabolism. FASEB# 112.3, 2012.
    • Wang Y, Yang M, Vance TM, Lee SG, Davis CG, Chun OK, Koo SI. Dietary antioxidant density in usual diet improves inflammatory biomarkers in overweight postmenopausal women, FASEB# 119.5, 2012.
    • Yang M, Wang Y, Davis CG, Lee SG, Fernandez ML, Koo SI, Cho E, Chun OK. Seasonal change in antioxidant intakes and major food sources in overweight postmenopausal women. FASEB# 813.7, 2012.
    • Lee SG, Nam TG, Kim DO, Lee J, Koo SI, Chun OK. Anthocyanin compositions and contents influence the antioxidant capacities of berries. FASEB# 2012.
    • Lee SG, Park Y, Lee J, Koo SI, Chun OK. Berry anthocyanin fractions inhibits LPS-induced expression of inflammatory mediators in RAW 264.7 macrophages. FASEB# 2012.
    • Lee SG, Nam TG, Kim DO, Koo SI, Chun OK. Comparison of analytical methods for anthocyanin quantification in berries. FASEB# 2012.
    • Masterjohn C, Guo Y, Noh SK, Koo SI, Bruno RS. Normalization of dietary fructose-induced liver injury in rats by green tea extract is accompanied by lower hepatic methylglyoxal accumulation. FASEB J. #95.3, 2011.
    • Chung M-Y, Noh SK, Masterjohn C, Park HJ, Clark RM, Park Y-K, Lee J-Y, Koo SI, Bruno RS. Green tea extract protects against hepatic inflammation by reducing cyclooxygenase-2 in a rat model of a dietary fat-induced nonalcoholic steatohepatitis. FASEB #106.2, 2011.
    • Wang Y, Yang M, Lee S-G, Davis CG, Koo SI, Chun OK. Plasma total antioxidant capacity reflects plasma antioxidant status in overweight postmenopausal women. FASEB #771.13, 2011.
    • Wang Y, Yang M, Davis CG, Koo SI, Chun OK. Dietary total antioxidant capacity reflects dietary and plasma antioxidant status in healthy college students. FASEB #773.17, 2011.Floegel A, Kim DO, Chung SJ, Song WO, Koo SI, Chun OK. Development and validation of an algorithm to establish a total antioxidant database of U.S. diet. FASEB J, #221.5, 2010.
    • Park HJ, Chung M-Y, Park YK, Lee JY, Koo SI, Bruno RS. Green tea extract (GTE) protects against nonalcoholic fatty liver disease in diet-induced obese rats by decreasing hepatic inflammatory and oxidative stress responses. IFT 2010.
    • Park HJ, Chung M-Y, Koo SI, Bruno RS. Green tea extract (GTE) attenuates adipose inflammation by restoring glutathione redox status in high fat diet-induced nonalcoholic fatty liver disease. FASEB J, #722.15, 2010.
    • Chung MY, O’Connor, M, Park HJ, DiNatale D, Koo SI, Manautou J, Bruno RS. GTE reduces hepatic injury by inhibiting lipid accumulation and peroxidation in steatotic livers of obese mice. FASEB J, #563.23, 2009.
    • Park HJ, Dinatale DA, Chung MY, Koo SI, Park YK, Lee JY, Bruno RS. Green tea extract attenuates hepatic injury by reducing oxidative stress and lipid accumulation in ob/ob mice. FASEB J, #563.34, 2009.
    • DiNatale DA, Park HJ, Chung MY, Koo SI, Bruno RS. Green tea extract protects against nonalcoholic fatty liver disease by decreasing liver injury and improving enzymatic antioxidant defenses. FASEB J, #718.5, 2009.
    • Kim J, Noh SK, Seo Y, Koo SI. Green tea extract enhances the biliary secretion of benzo[a]pyrene (BaP) in rats. FASEB J. #721.7, 2009.
    • Koo, S.I. and Noh, S.K. Green tea extract is more effective than epigallocatechin gallate and epicatechin in inhibiting the lymphatic absorption of cholesterol and other lipids. FASEB J. #701.8, 2008.
    • Noh, S.K., Kim, J., Seo, Y. and Koo, S.I. Green tea extract lowers the lymphatic absorption of benzo[a]pyrene in rats. FASEB J. #315.5, 2008.
    • Seo, Y., Kim, J., Noh, S.K., and Koo, S.I. Enteral capsaicin lowers the lymphatic absorption of cholesterol in rats. FASEB J. #704.2, 2008.
    • Shrestha, S., Ehlers, S.J., Lee, J-Y., Fernandez, M-L., and Koo, S.I. Dietary green tea extract (GT) lowers the plasma and hepatic triglyceride (TG) with an increase in plasma HDL-cholesterol (HDL-C) and decreases in SREBP1c mRNA and its responsive genes in fructose-fed ovariectomized (OX) rats. FASEB J. #542.6, 2007.
    • Dugan, C.E., Dinatale, D.A., Smyth, J.A., Koo, S.I., and Bruno, R.S. Green tea extract attenuates hepatic steatosis and injury in leptin-deficient mice, FASEB J. #542.7, 2007.
    • Clark, R.M., Balakrishnan, A., Waters, D., Aggarwal, D., Owen, K.Q., and Koo, S.I. L-Carnitine increases liver alpha-tocopherol and lowers liver and plasma triglycerides in aging ovariectomized rats. FASEB J. #695.1, 2007.
    • Vaishnav, U., Puglisi, M.J., Leite, J.O., Volek, J.S., Bruno, R.S., Koo, S.I., and Fernandez, M-L. Effect of green tea extract on postprandial lipid response to an oral fat load. FASEB J. #847.9, 2007.
    • Shrestha, S., Odom, D., McGrane, M., Fernandez, M-L., and Koo, S.I. Dietary green tea extract (GT) lowers plasma triglyceride (TG) and the abundance of liver and intestinal microsomal TG transfer protein (MTP) mRNA in fructose-fed ovariectomized (OX) rats. FASEB J. (submitted), 2006.
    • Lofgren, I., Herron K.L., West, K.L., Zern, T.L., Brownbill, R., Ilich J, Koo, S.I. and Fernandez, M.L. A Weight loss program favorably modifies anthropometrics and reverses the metabolic syndrome and insulin resistance in premenopausal Women. FASEB J. #593.14, 2005.
    • Noh, S.K. and Koo, S.I. Luminal infusion of phytic acid lowers the lymphatic absorption of cholesterol (CH) and a-tocopherol (aTP) in rats. FASEB J. #576.5, 2004.
    • Patalay, M., Lofgren, I., Freake, H.C., Koo, S.I. and Fernandez, M.L. The lowering of plasma lipids following a weight reduction program are related to increased expression of the LDL receptor and lipoprotein lipase (LPL) in isolated mononuclear cells. FASEB J. #577.19, 2004.
    • Lofgren, I., Herron, K., Patalay, M., West, K., Zern, K., Brownbill, R., Ilich-Ernst, J., Koo, S.I. and Fernandez. Identifying risk factors for chronic disease in overweight premenopausal women. FASEB J. #117.2, 2004.
    • Zern, T.L., Lofgren, I., Herron, K., West, K.L., Patalay, M., Sharma M., Volek, J.S., Koo, S.I. and Fernandez, M.L. Weight loss intervention results in less atherogenic LDL particles in premenopausal women. FASEB J. #578.3, 2004.
    • Mettel, J.B., West, K.L., Lofgren, I.E., Fernandez, M.L., Koo, S.I. and Rodriguez, N.R. Effects of a weight loss intervention program on substrate oxidation in pre-menopausal women. FASEB J. #123.4, 2004.
    • Koo, S.I. Marginal zinc deficiency decreases intestinal retinol and beta-carotene absorption. Is the decrease attributable to a defect in luminal phosphatidylcholine hydrolysis? Carotenoid Research Interactive Group (CARIG) Conference, Invited speaker, Experimental Biology 2003, San Diego, CA.
    • Noh, S.K. and Koo, S.I. Milk sphingomyelin (SM) is a more potent inhibitor that egg SM of intestinal cholesterol absorption in rats. FASEB J. 17:A754, 2003.
    • Koo, S.I., Wang, S. & Noh, S.K. (+)-Catechin is a potent inhibitor than resveratrol of the intestinal absorption of cholesterol in ovariectomized rats. FASEB J. 16: A645, 2002.
    • Noh, S.K. & Koo, S.I. Luminal infusion of sphingomyelin lowers the lymphatic absorption of cholesterol and alpha-tocopherol in rats. FASEB J. 16: A632, 2002.
    • Wang, S., Noh, S.K. & Koo, S.I. Green tea epigallocatechin gallate inhibits the luminal hydrolysis and lymphatic output of phosphatidycholine and lowers the lymphatic absorption of fat and ?-tocopherol in ovariectomized rats. FASEB J. 16: A644, 2002.
    • Koo, S.I., Noh, S.I., and Jiang,Y. (+)-Catechin lowers the lymphatic absorptions of cholesterol in rats.FASEB J.15:757.5, 2001.
    • Löest, H, Noh, S.K., and Koo, S.I. Intraduodenal infusion of green tea decreases the lymphatic absorption of cholesterol in ovariectomized rats. FASEB J. 15: 757.3, 2001.
    • Noh, S.K. and Koo, S.I. The lymphatic output of retinol is decreased in marginally zinc deficient rats infused intraduodenally with ß-carotene. FASEB J. 15:740.9, 2001.
    • Zou, W., Noh, S.K., Loest, L., and Koo, S.I. Epigallocatechin gallate and quercetin lower the lymphatic absorption of cholesterol in rats. FASEB J. 15:757.4, 2001.
    • Wang, S., Noh, S.K., and Koo, S.I. Green tea catechins inhibit pancreatic phospholipase A2 activity in vitro.FASEB J. 15:LB305, 2001.
    • Koo, S.I., Zou, W., Noh, S.K., Gross, K.L., and Owen, K.Q. Dietary carnitine increases the liver level and biliary secretion of a-tocopherol (aTP) in ovariectomized (OX) rats. FASEB J. 14:357.7, 2000.
    • Noh, S.K. and Koo, S.I. Enteral lysophosphatidylcholine (LPC) restores the lymphatic absorption of retinol (ROH) and a-tocopherol (aTP) in zinc deficient (ZD) rats. FASEB J. 14:360.6, 2000.
    • Jiang, Y.Z., Noh, S.K., and Koo, S.I. Egg phosphatidylcholine (PC) decreases the lymphatic absorption of cholesterol in rats. FASEB J. 14:175.2, 2000.
    • Zou, W., Koo, S.I., Noh, S.K., Gross, K.L., and Owen, K.Q. Dietary carnitine enhances the lymphatic absorption of a-tocopherol (aTP) in ovariectomized (OX) rats. FASEB J. 14:357.8, 2000.
    • Koo, S.I., Zou, W., Noh, S.K., Gross, K.L., and Owen, K.Q. Dietary carnitine increases the liver level and biliary secretion of a-tocopherol in ovariectomized rats. FASEB J.14:A505.
    • Koo, S.I., Noh, S.K. and Zou, W. Enteral phosphatidylcholine (PC) infusion lowers the lymphatic absorption of a-tocopherol in zinc-deficient rats with bile diversion. FASEB J.13:214.16, 1999.
    • Noh, S.K. and Koo, S.I. Marginal zinc deficiency lowers the lymphatic absorption of ?-tocopherol (?TP) and enteral infusion of phosphatidylcholine (PC) further lowers (TP absorption. FASEB J.13:214.16, 1999.
    • Koo, S.I. and Noh, S.K. Estradiol replacement (ESR) elevates the liver levels and biliary secretion of phospholipid 22:6 (DHA) and a-tocopherol ((TP) in ovariectomized (OX) rats fed soybean oil. FASEB J. 12:A840, 1998.
    • Noh, S.K. and Koo, S.I. Feeding of a marginally low level of dietary zinc lowers the concentrations of ?-tocopherol (aTP) in selected tissues.FASEB J.12:A217, 1998.
    • Noh, S.K., Kim, E.S., Chung, H.J. and Koo, S.I. Enteral infusion of glucose or alanine plus glycine, not glutamine, increases the absorption of 14C-triolein and alpha-tocopherol (?TP). The increase is associated with a rise in lymphatic glucose output. FASEB J. 11:A382, 1997.
    • Chung, H.J., Noh, S.K., Chu, A and Koo, S.I. Estradiol (ES) replacement in ovariectomized rats elevates markedly serum a-tocopherol (aTP), with a selective increase in HDL aTP. FASEB J. 11:A412, 1997.
    • Koo, S.I., Chung, H.J., and Noh, S.K. The lymphatic absorption of a-tocopherol (aTP) and serum HDL aTP are markedly increased by estradiol replacement in ovariectomized rats. The 16th International Congress of Nutrition Abstracts 117: PM186, 1996.
    • Noh, S.K and Koo, S.I. Intraduodenal phosphatidylcholine (PC) infusion restores fully the lymphatic absorption of lipids in ovariectomized (OX) rats with estrogen replacement (ER).FASEB J. 10:A521, 1996.
    • Kim, E.S., Noh, S.K. and Koo, S.I. Direct evidence for the impaired lymphatic absorption of ?-tocopherol ((TP) in marginally zinc deficient (ZD) rats. FASEB J. 10:A528, 1996.
    • Koo, S.I. and Ahn, J. Lymphatic absorption of vitamin A and fatty acid is restored to normal in zinc deficient rats by intraduodenal infusion of phosphatidylcholine. FASEB J. 9:A166, 1995.
    • Yang, L. and Koo, S.I. Ovariectomy results in increases in body weight and fat and estradiol replacement elevates serum and tissue free fatty acids (FFAs) in ovariectomized rats. FASEB J. 9:A466, 1995.
    • Ahn, J., Choi, I.W. and Koo, S.I. Effect of zinc deficiency on the plasma clearance and hepatic uptake of 3H-retinyl palmitate (ROP) in rats. FASEB J. 8:A2572 1994.
    • Yang, L., Frye, A. and Koo, S.I. Effects of estrogen replacement on the lymphatic absorption of lipids in ovariectomized rats. FASEB J. 8:A4264, 1994.
    • Koo, S.I. and Yang, L. Estradiol replacement delays induction of copper deficiency and copper repletion increases plasma HDL-cholesterol in ovariectomized rats. FASEB J. 7: A803, 1993.
    • Ahn, J. and Koo, S.I. The lymphatic absorption of retinol and secretion of phospholipid are impaired in zinc and essential fatty acid deficient rats. FASEB J. 7:A511, 1993.
    • Koo, S.I. and Ahn, J. The effect of zinc status on the intestinal absorption and tissue uptake of 3H-retinol in rats. XV International Congress of Nutrition (Adelaide, Australia) 15:818, 1993.
    • Koo, S.I. and Lee, C.C. Plasma clearance of cholesterol via VLDL does not reflect an increase in the liver synthesis of cholesterol in copper deficient rats. FASEB J. 6:A1106, 1992.
    • Wang, S. and Koo, S.I. Evidence for distinct metabolic utilization of stearic acid in the liver, compared with palmitic and oleic acid. FASEB J. 6:A1384, 1992.
    • Brenner, G.M. and Koo, S.I. Interactive effects of copper status and estradiol replacement on HDL cholesterol and copper levels in female rats. FASEB J. 6:A1096, 1992.
    • Koo, S.I., Peterson, D.F. and Mason, P.A. Effect of dietary copper and sucrose on catecholamine concentrations in the adrenal medulla. FASEB J. 5:A584, 1991.
    • Koo, S.I., Lee, C.C. and Sabin, L. Effect of copper deficiency on the hepatic synthesis and rate of secretion of cholesterol in male rats. FASEB J. 4:A1545, 1990.
    • Peterson, D.F., Koo, S.I. and Lee, C.C. Interactive effects of dietary copper and carbohydrates on serum cholesterol and minerals. FASEB J. 4:A1550, 1990.
    • Ray, D.B., Lee, C.C and Koo, S.I. Hepatic apolipoprotein A-I mRNA is decreased in copper-deficient rats. FASEB J. 3:A1062, 1989.
    • Carter, J., Koo, S. and Goljan, E. Evaluation of different dietary zinc levels on serum components in rabbits.FASEB J. 3:A1080, 1989.
    • Rhee, H.M., Peterson, D.F. and Koo, S.I. Effect of forced running stress on plasma catecholamines and cholesterol: an involvement of opioid receptor. Am. J. Hypertension 2(5):72a, 1989.
    • Koo, S.I., Lee, C.C., Scott, R.L. and Stone, W.L. Plasma clearance of human 125I-low density lipoproteins (LDL) in copper-deficient rats. FASEB J. 3:A1062, 1989.
    • Lee, C.C. and Koo, S.I. Effect of menhaden fish oil on plasma cholesterol in copper-deficient rats. FASEB J. 3:A357, 1989.
    • Lee, C.C. and Koo, S.I. Compositional characterization of three plasma high density lipoprotein (HDL) subclasses in copper-deficient rats. FASEB J. 2:A854, 1988.
    • Koo, S.I., Lee, C. and Norvell, J.E. Copper deficiency decreases intestinal absorption of cholesterol and postheparin lipase activities, but does not alter chylomicron clearance. FASEB J. 2:A853, 1988.
    • Brenner, G and Koo, S.I. Effect of estradiol on serum HDL-cholesterol, and serum and tissue distribution of zinc and copper in ovariectomized rats. FASEB J. 2:A1218, 1988.
    • Lee, C.C, Koo, S.I. and Norvell J.E. Effect of zinc deficiency on postheparin, adipose and muscle lipoprotein lipase activities in the rat. Fed. Proc. 46:1472, 1987.
    • Koo, S.I. and Lee, C.C. Composition of high-density lipoproteins (HDL) and HDL subclasses of marginally zinc-deficient rats. Fed. Proc. 46:1472, 1987.
    • Lee, C.C., Koo, S.I. and Norvell, J.E. Effect of marginal zinc deficiency on the apoprotein (Apo) B concentration of lymph chylomicrons. Fed. Proc. 45:974, 1986.
    • Carter, J.W. and Koo, S.I. Effect of zinc-deficient diets on the cardiovascular system in rabbits. Fed. Proc. 45:1083, 1986.
    • Koo, S.I., Norvell, J.E., Algilani, K. and Chow, J. Effect of marginal zinc deficiency on the lymphatic absorption of 14C-cholesterol. Fed. Proc. 45:974, 1986.
    • Koo, S.I., Algilani, K. and Norvell, J.E. Marginal zinc deficiency delays the rate of plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in the rat. Fed. Proc. 44:1505, 1985.
    • Algilani, K., Dodds, S., Koo, S.I. and Mercer, L.P. Relationship of zinc and copper with serum lipoprotein cholesterol and lecithin:cholesterol acyltransferase (LCAT) activity in the rats fed varying levels of histidine. Fed. Proc. 44:1508, 1985.
    • Carter, J.W., Koo, S.I., Miller-Hardy, D.K. and Goljan, E.F. Effect of dietary Aroclor 1254 (PCBs) on atherosclerosis in pigeons. Fed. Proc.44:1158, 1985.
    • Koo, S.I., Algilani, K., Hung, C.P., Henderson, D.A. and Norvell, J.E. Effect of marginal zinc deficiency on the intestinal absorption of 14C-cholesterol and composition of lymphatic chylomicrons. Fed. Proc. 43:685, 1984.
    • Henderson, D.A., Koo, S.I., Algilani, K and Algilani, A. Altered morphology of chylomicrons in jejunum and blood of marginally zinc-deficient rats. Fed. Proc. 43:823, 1984.
    • Carter, J.W., Mercer, L.P. and Koo, S.I. Dietary PCBs (Aroclor 1254) produces hypercholesterolemia in Fischer rats. Southwestern Assoc. Toxicol. May, 1983.
    • Koo, S.I. Dietary linoleic acid reduces serum levels of zinc and HDL-cholesterol. Fed. Proc. 42:3104, 1983.
    • Koo, S.I. Effect of nutritional status of zinc on the concentration of high-density lipoprotein cholesterol. Fed. Proc. 40:839, 1981.
    • Koo, S.I. and Williams, D.A. New evidence for positive correlation between serum zinc and HDL-cholesterol and Its significance in coronary heart disease. Am. Chem. Soc. (March). 5, 1981.
    • Koo, S.I., Fullmer, C.S. and Wasserman, R.H. Intestinal absorption and retention of 109Cd. Fed. Proc. 37:405, 1978.

PATENTS

    • Koo, S.I., Hua, D., and Noh, S.K. Compounds Affecting Cholesterol Absorption. U.S. Patent Number 6,727,277. (Issued April 27, 2004), U.S. Patent and Trademark Office.
    • Koo, S.I. Phosphatidylcholine Compositions and Methods to Reduce Intestinal Absorption and Plasma Levels of Cholesterol. US Patent Number 6,248,728, Issued June 19, 2001. U.S. Patent and Trademark Office.
    • Koo, S.I., Owen, K., Noh, S., Gross, K., and Zou, W. Supplemental L-Carnitine Enhances the Intestinal Absorption and Body status of Vitamin E. S/N 60/188,419. U.S. Patent and Trademark Office, Application filed March 10, 2000.
    • O’Quinn, P., Koo, S.I., Nelssen, J., Goodband, R., Tokach, M., and Owen, K. Use of Modified Tall Oil or Conjugated Linoleic Acid in Combination to Improve Body Composition and Health Status. S/N 09/608,817. U.S. Patent and Trademark Office, Application review pending.
    • Hua, D.H., Koo, S.I., and Noh, S.K. Inhibitors of Lymphatic Absorption of Cholesterol, New Drugs for Lowering Intestinal Absorption of Cholesterol: (4aS,6aR,12bS)-2H-11-Chloro-1,3,3,4a-12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene-9-10-diol and its Derivatives. Disclosure filed by KSURF, June 5, 2002.